The NHS has issued a warning about the long-term use of omeprazole, the UK’s most prescribed drug. More than 73 million prescriptions were given in England between 2022 and 2023. Around 15 percent of the population currently takes it.
Omeprazole is used to treat acid reflux, heartburn, and ulcers. It works by reducing stomach acid, helping many patients find relief. But doctors stress that long-term use comes with serious risks. Common side effects include headaches, nausea, and stomach pain.

The NHS lists four more dangerous side effects. These include low vitamin B12, weakened bones, allergic reactions, and lupus-like symptoms causing rashes and joint pain. “Do not take omeprazole for longer than two weeks if you bought it without a prescription,” the NHS advised.
While rare, risks increase if the drug is taken for over a year. Experts also warn it could mask other illnesses. Would you risk long-term use, or check with your GP before continuing?