ITV’s resident doctor, Dr Amir Khan, has shared an important warning for anyone taking omeprazole for heartburn, acid reflux, or stomach ulcers. The medication, known as a proton pump inhibitor (PPI), lowers stomach acid and helps irritated tissues heal. Many people use it safely when prescribed by a doctor.
Why Long-Term Use Matters
While omeprazole works well, Dr Khan reminded viewers that taking it for long periods may affect the body’s ability to absorb key nutrients. Low stomach acid can lead to low vitamin B12, magnesium, and calcium. These shortages may cause tiredness, weak bones, dizziness, muscle cramps, or irregular heartbeat.

He stressed that people should never stop the medication suddenly. Anyone with concerns should talk to their GP or pharmacist first.
Dr Khan’s Advice to Patients
Speaking to his 788,000 Instagram followers, Dr Khan explained three common issues linked to long-term PPI use—and what patients can do:
- Check your nutrient levels if you have taken PPIs for a long time.
- Eat a balanced diet rich in leafy greens, nuts, and dairy to help support vitamin and mineral levels.
- Ask your GP about reducing your dose or using the medication only when needed, if symptoms are well controlled.
Possible Health Risks Over Time
Long-term omeprazole use may lead to:
- Vitamin B12 deficiency, which can cause confusion, nerve problems, and dizziness.
- Low magnesium, which may lead to tiredness, cramps, or heart rhythm issues.
- Low calcium or iron, which can weaken bones and affect overall health.
- Higher infection risk, including C. diff, a severe gut infection linked to low stomach acid.
- A short-term rise in pneumonia risk, according to some studies.
- Increased risk of bone fractures after a year or more of high-dose use.
- Kidney problems, including a higher risk of chronic kidney disease.
- Stomach polyps, which are usually harmless but linked to long-term PPI therapy.
Omeprazole is effective and safe when used correctly. But Dr Khan urges patients to stay informed, monitor their health, and always seek medical advice before making any changes.