A landmark study of over two million patients has revealed the long-term risks and rewards of popular weight-loss drugs like Ozempic and Wegovy. While these “miracle” jabs offer major health perks, they also carry significant side effects that patients should recognize.
The research shows that users have double the risk of developing pancreatitis. This is a dangerous inflammation of the pancreas that can lead to severe stomach pain and even organ failure. Additionally, users face a 30% higher chance of suffering from nausea and vomiting.

Surprisingly, the study linked these drugs to an 11% higher risk of arthritis and joint pain. Some experts believe this happens because patients become more active after losing weight, which may put new stress on their joints. Other reported issues include kidney stones, fainting, and sleep disturbances.
Despite the risks, the drugs provide clear protection for the heart and brain. Users showed a lower risk of stroke, heart attacks, and seizures. Even more promising, the data suggested a reduced risk of developing dementia and Alzheimer’s disease.
Doctors emphasize that these medications are not risk-free. While they can be life-changing for weight loss, the potential for severe reactions is real. It is important to discuss the balance of benefits and risks with a healthcare provider before starting any new treatment.