As Ozempic gains popularity for weight loss, some users are reporting unexpected changes in their sex drive. While the drug is officially approved to treat Type 2 diabetes, many people now take it off-label to suppress appetite and shed pounds.

Ozempic works by mimicking the GLP-1 hormone, which reduces hunger, stabilizes blood sugar, and quiets “food noise.” This helps users feel full longer and reduce cravings. Common side effects include nausea, vomiting, and constipation. However, some users have also reported less common effects—like muscle weakness, “Ozempic butt,” and a decline in sexual desire.

One Reddit user described feeling completely uninterested in intimacy, saying the thought of sex felt almost nauseating. The shift created tension in their relationship.

Psychologist Dr. Rachel Goldman of NYU Grossman School of Medicine explained that GLP-1 medications affect the brain’s reward system. This may explain the drop in cravings—not only for food or alcohol—but also for sex. She noted that while some patients report decreased libido, others experience the opposite.

Goldman added that these mismatched shifts in desire could strain relationships, especially if partners aren’t aligned.

Ozempic manufacturer Novo Nordisk emphasized that patients should only use the drug under medical supervision and report any side effects to their healthcare provider.