On May 23, Rosie O’Donnell shared a stage selfie in a green top and dark pants, proudly showing off her slimmer figure. “I can’t believe this is me now,” she captioned the post—prompting fans to gush over her new look.

Followers flooded the comments with praise. “You look amazing—you’ve lost so much weight,” one wrote. Another admitted, “I didn’t recognize you at first!” The outpouring highlighted the impact of her visible change.

Rosie credits much of her weight loss to Mounjaro (tirzepatide), an injectable diabetes drug with weight-loss side effects. “My appetite has decreased significantly. It’s probably the meds,” she explained. Alongside weekly injections, she’s cut back on sugar, upped her water intake, and moved more each day.

Since relocating to Ireland with her 12-year-old son, Clay, Rosie has been cooking for her family—no private chef required. She’s also adjusted her wardrobe, swapping elastic-waist pants for regular fits in Dublin stores.

By combining Mounjaro with healthier habits and a fresh environment, Rosie O’Donnell’s candid journey shows how small, consistent changes can spark remarkable results.